Antibiotics are medicines that can be used prophylactically or espec ficamente.Lo which means that one must know the pathogen prior indications, the general conditions of the patient and the effectiveness of the antibiotic on bacteria. We must recognize that there are states of oral health and systemic antibiotics in which case do not fulfill their purpose, controlling the infection.But there protocols for oral surgery procedures, as part of this strategy are given prophylactic antibiotics because we know that in the normal bacterial flora of the mouth are primarily gram positive aerobes and some anaerobes (mixed flora). This directs us to the use of semi synthetic penicillins, first generation cephalosporins as first choice in combination with metronidazole or clindamycin use, when we suspect of anaerobes.We consider that the use of oral antiseptics such as chlorhexidine 0.12 , the saline solution with diluted hydrogen peroxide (10-3), help balance the ph mouth immediately, being part of the protocol, but considering that the excess time and dosage, users may become injurious. Knowledge of the effect of antibiotics allows us to know for example that penicillin acts by preventing the synthesis of the bacterial membrane when it is in mitosis (division and growth), because when they are inactive, those antibiotics can not act by the presence of peptidoglycans (substance responsible for resisting the extracellular osmotic pressure), therefore will be vulnerable only when they grow. Protocols help us if we know how to vary the treatment as it will be very different from treating people with systemic disorders like diabetes, liver disease, with heart disease, or kidney disease. It is therefore essential that dentists have knowledge of clinical medicine and pharmacotherapy and the implementation of biosafety standards, since, aseptic, handling contaminated instruments and materials, surface treatment and equipment used in surgery.